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KMID : 1007520030120060649
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Food Science and Biotechnology
2003 Volume.12 No. 6 p.649 ~ p.653
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Induction of Cellular Quinone Reductase by Some Flavonoids
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Kwon, Chong-Suk
Kim, Ji Hyun/Son, Kun Ho/Kim, Young-Kyoon/Kim, Woo Keun/Kim, Jong-Sang
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Abstract
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Induction of quinone reductase (QR;NAD(P)H:(quinone-acceptor) oxidoreductase), which promotes an obligatory two-electron reduction of quinones and prevents their participation in oxidative cycling and, thereby, the depletion of intracellular glutathione, has been used as a marker for chemopreventive agents. Induction of phase 2 enzymes is considered to be an important mechanism of cancer prevention. To search for novel cancer preventive agents, we assessed the QR-inducing activities of some flavonoids in cultured murine hepatoma cells. Among fifteen flavonoids tested in this study, baicalin, ginkgetin, isoginkgetin, linarin, and luteolin significantly induced QR activity in hepac1c7 cells. Cinkgetin and luteolin at the concentration of 0.5㎍/mL induced QR by 31 and 24%, respectively. Isoginkgetin and linarin induced QR in a dose-dependent manner, by 33 and 49%, respectively at the concentration of 9㎍/mL. Bilobetin, ginkgetin, and isoginkgetin induced QR in both hepa1c1c7 and its mutant BPRc1 cell lines. In short, these flavonoids with significant QR-inducing activities merit further animal and clinical studies to assess their potential as cancer preventive agents.
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